Sign Out
OVERDOSE AND TREATMENT: Symptoms of overdose include somnolence, nausea, vomiting, tachycardia, ECG changes, anxiety and dilated pupils. Treatment is primarily supportive and included monitoring and use of activated charcoal, gastric lavage or cathartics and hydration. Establish and maintain an airway, ensure adequate oxygenation and ventilation.
There are no specific antidotes for sertraline. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be considered in treating overdose. Cardiac and vital signs monitoring is recommended along with general symptomatic and supportive measures.
Due to the large volume of distribution of sertraline, force diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit.
